Borotherapeutics is an early stage drug development company that seeks to develop boron-based therapeutics targeting neurodegeneration, with a current focus on Amyotrophic Lateral Sclerosis (ALS). Our lead drug candidate, BorsantrazoleTM, has a demonstrated ability to delay disease onset, prevent ALS induced weight loss, and extend life in humanized preclinical ALS mouse models. Our aim is to translate our animal model results to patients, delaying ALS disease progression and improving quality of life.
Borotherapeutics is a start-up drug development company out of the University of Manitoba's College of Pharmacy. Borotherapeutics seeks to develop targeted boron-based therapies, with a patient focus, seeking to engage patients, caregivers, clinicians and scientists at all stages of drug development. Currently, we are looking to advance our lead boron-based drug candidate (BorsantrazoleTM) towards the clinic for neurodegeneration and Amyotrophic Lateral Sclerosis
Founders ALS drug development project funded by CIHR (5 years, $730,576).
Borotherapeutics co-founder awarded Mitacs Innovation Award - Outstanding Innovation
Co-founder awarded prestigious outstanding innovation award for contributions to the discovery of Borsantrazole. Awesome achievement!
Borotherapeutics lead ALS drug candidate, BorsantrazoleTM, is trademarked
Abstract 146
Discovery of Novel Phosphosites in hSOD1-G37R Preclinical Models Correlating with the Efficacy of Borsantrazole
Abstract 147
Introducing Borsantrazole: A Trifunctional Boron-based Pyrazole Increases Survival and Delays Disease Onset in the SOD1-G37R Mouse Model of ALS
Abstract TST-32: Global proteomic and phosphoproteomic biomarker profiling of a trifunctional boron-based pyrazole
Abstract TST-33: A trifunctional boron-based pyrazole increases survival, delays disease onset, and prevents ALS-induced cachexia in a hSOD1 model of ALS
Borotherapeutics Ltd.
Academic innovation with an inclusive stakeholder focus.
Based in Winnipeg, Manitoba, Canada.
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